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10.1249/mss.0b013e31802f04c7 38 FilaM.ChojnackiC.ChojnackiJ.BlasiakJ

Download figure Open in new tab Download powerpoint Figure 3 Working model of MET in KRAS-mutant NSCLC

Its catalytic Cys residue is buried at the base of a narrow pocket, differently from the other PRDXs, which renders PRDX6 unable to dimerize through disulfide formation in the native configuration, although it can homodimerize and multimerize through hydrophobic interactions (131)