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Importantly, it revealed inter-patient variability in response to chimeric antigen receptor (CAR)-T-cell therapy, capturing both effective tumor eradication and excessive cytokine release patterns that mirror clinical immune-related toxicities

The intramolecular disulfide bond between its two cysteine residues is believed to be important for maintaining its active conformation

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Summary Keywords glutathione, antioxidants, psychiatric disorders, suicide risk, mood disorders, oxidative stress Citation da Silva Schmidt PM, Trettim JP, Longoni A, Grings M, de Matos MB, de Avila Quevedo L, Ardais AP, Nedel F, Ghisleni G, Leipnitz G, Pinheiro RT and de Assis AM (2023) Can glutathione be a biomarker for suicide risk in women 18 months postpartum

Their findings indicate that elesclomol administration to colorectal cancer cells increased Cu(II) levels in the mitochondria, downregulated ATP7A expression, and increased ROS accumulation