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How to Minimize Injection Site Reactions Several simple strategies can reduce irritation: Rotate injection sites consistently between the abdomen, thighs, or other provider-approved areas Avoid injecting into irritated, bruised, or scarred skin Allow refrigerated medication to reach room temperature before injecting Use proper injection technique and needle angle Inject slowly rather than rapidly Avoid rubbing the injection area afterward Many providers also recommend taking sermorelin at bedtime because growth hormone release naturally peaks during sleep