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doi: 10.3389/fendo.2025.1573526 Received 09 February 2025 Accepted 15 September 2025 Published 01 October 2025 Volume 16 - 2025 Edited by Claus Yding Andersen, University of Copenhagen, Denmark Reviewed by Gennaro Lettieri, University of Naples Federico II, Italy Anitha Myla, Mississippi State Department of Health, United States Updates Copyright 2025 Han and Jin

224 The lysine deacylase activity of SIRT4 is involved in the control of leucine metabolism and insulin secretion through regulating the acylation status of enzymes in these pathways