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The primary methods use epichlorohydrin as the starting material, differing in whether the chemical resolution is performed at different stages of the reaction or a chiral reagent is introduced before the reaction for asymmetric induction to obtain L-carnitine

and the covariance parameters related to the variance between donors are 0,2 for cortex, 2,0 for IRS and 2,8 for ORS ||

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In highly trained individuals with already optimized nutrition, the effects may be more subtle and mostly related to recovery or endurance rather than dramatic performance increases

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