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Environmental influences such as nutrition, stress, and disease can affect the postnatal health and development of an organism, per the developmental origin of health and disease (DOHaD) theory

It might slow down neurodegenerative diseases by improving DNA repair and reducing oxidative damage

In the future, the integration of metabolomic readouts, single-cell and spatial transcriptomic localization, and metabolic modeling analysis is expected to establish a research framework of metabolic stratification-target selection-efficacy prediction, thereby reducing the risk of failed extrapolation across different diseases or populations (138)

doi: 10.3389/fphar.2025.1592458 Received 12 March 2025 Accepted 07 July 2025 Published 31 July 2025 Volume 16 - 2025 Edited by Marcello Iriti, University of Milan, Italy Reviewed by Quansheng Feng, Chengdu University of Traditional Chinese Medicine, China omali Y El-khawaga, Mansoura University, Egypt Updates Copyright 2025 Wang, Yan, Zhang, Wang, Jiao, Zhu, Tan and Yang

Alam SB, Wagner A, Willows S, Kulka M

Cell lysates were incubated for 30 minutes on ice and then centrifuged at 12,000g for 15 minutes at 4 C