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Once in the tissues, ALA can be found inside and outside the cells including inside the mitochondria where it functions naturally as a coenzyme for the oxidation of pyruvate, alpha ketoglutarate, and branched-chain amino acids.*

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Huilcaman R, Venturini W, Fuenzalida L, Cayo A, Segovia R, Valenzuela C, et al

33 In addition, endothelial cells treated with GSH exhibit blockade of NF-B activity decreased expression of NF-B downstream target gene inter-cellular adhesion molecule-1 (ICAM-1)