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Acknowledgments The authors would like to thank the patients for their participation in this study and permission to publish

doi:10.1007/978-0-387-46401-5_1

While the experimental models employed in PD have shown connections to human health, it remains a daunting task to translate mechanisms of action observed in in vitro and in vivo studies of natural compounds to clinical outcomes in human trials, where it is a critical step in drug development

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Formation of Microparticles (MPs): MPs are membrane vesicles released from membrane budding following loss of phospholipid asymmetry and cleavage of the underlying cytoskeleton