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Increased expression of the copper efflux transporter ATP7A mediates resistance to cisplatin, carboplatin, and oxaliplatin in ovarian cancer cells

Hou W, Xie Y, Song X et al (2016) Autophagy promotes ferroptosis by degradation of ferritin

We recognize the critical need for future studies to validate these using human-derived cell lines and PDX models to confirm the translational significance of our results, and are developing and testing strategies for utilizing immunodeficient mice for studies of obesity and cancer [40]

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In addition, ten genes (such as anti-ACSL3 antibody (ACSL3), GPX4, and SLC7A11) associated with ferroptosis have been postulated to have regulatory roles in lung adenocarcinoma (15)

In the final step to the coenzyme, CobC removes the 5' phosphate group: [32] [33] Adenosylcobalamin-5'-phosphate + H 2 O adenosylcobalamin + phosphate The complete biosynthetic route involves a long linear path that requires about 25 contributing enzyme steps