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Ray et al., 2012), phosphorylation of proteins, action on ionic channels and transcription factors, production of thyroid hormones and crosslinking on extracellular matrix ( The body tries to maintain redox homeostasis between the production of RONS and the capacity for their removal by antioxidant systems (Zuo et al., 2015), which allows the redox state to be re-established after temporary exposure to high concentrations of RONS and minimize the risk of a deteriorated redox homeostasis, which is an unbalanced state known as OS (Sies, 1986

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For the construction of the HEK293T Flag-Sororin stable cell line, pLenti-Flag-Sororin was co-transfected into HEK293T cells alongside two helper plasmids: pMD.2 G and psPAX2

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More severe cases of iodine deficiency result in impaired thyroid hormone synthesis known as hypothyroidism