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However, OCTN1 and OCTN2 both have narrower substrate specificity compared to polyspecific OCTs and OATs, and uptake assays performed with a large panel of drugs suggest that OCTN2 is not a general drug transporter 3,12,17,18

Following assembly, HDL particles undergo continual remodelling of both lipids and proteins, through interactions with enzymes such as lipases, acyltransferases, lipid transfer proteins and scavenger receptors for proteins