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Moderately low serum B12 concentrations between 148 or 150 and 221pmol/L or 260pmol/L are often considered indicative of depleted or subclinical B12 deficiency

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doi: 10.1136/pmj.79.930.218

Vitamin B12 supplements are recommended to population groups at higher risk for developing vitamin B12 deficiency: everyone (no matter what their diet) over 50 years old, people with diseases of the gastrointestinal system such as Chrohns and IBS, women on oral contraceptives and people who regularly use nitrous oxide or are alcoholics

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Ive recently been approached by a Company who have a transdermal delivery gel that delivers Carnosine and Magnesium right into the muscle