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High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation

Tripathi SK, Biswal BK

It May help fight against autoimmune disease The chronic inflammation caused by autoimmune diseases can increase oxidative stress

The negligible increment of ascorbate-glutathione content, ascorbate-glutathione redox and ascorbate-glutathione cycle enzymes activities and dramatic increment in malondialdehyde (MDA), hydrogen peroxide (H 2 O 2 ) and EL were observed in the sensitive genotype VA15

4.3 Effect of cognitive effort and sustained cognitive effort on GSH levels The cognitive effort (or task performance) per se did not have any significant effect on GSH levels in either region or either age group

This creates an immediate antioxidant surge in the blood, but not necessarily inside the cells where glutathione is actually required to function