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Factors that may disrupt healthy estrogen detoxification include alcohol, insulin resistance, obesity, oral contraceptives, and HRT

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However, recent studies demonstrated that bone quality can be compromised in obesity [216, 217]

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Effect of Alcohol Withdrawl on Glutathione S-transferase, Total Antioxidant Capacity and Amylase in Blood and Saliva of Alcohol-Dependent Males Wilson, D., et al

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