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Anti-angiogenesis: From tumor starvation to vessel normalization For most species, the formation of functional vessel needs maturation process [19]

2.2 Gene mutations and drug target alterations The development of drug resistance in Mtb is predominantly driven by genetic mutations that alter drug targets or drug activation pathways, reducing the efficacy of anti-tubercular agents

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37 and Supplementary Fig

For example, collagen peptides from chicken skin gelatin exhibit potent antioxidant activity, with the less than 2 kDa fraction effectively scavenging hydroxyl and superoxide radicals, chelating Fe 2+ , and significantly inhibiting lipid oxidation and peroxide formation, outperforming commercial antioxidants such as trolox and ascorbic acid [90]