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Chronic inflammatory responses happen much later, perhaps through uptake and metabolism (bioactivation) of NNK/nicotine in macrophages (Figure 2)

Smokers deprived of cigarettes for 72 h: Effect of nicotine patches on craving and withdrawal

and worldwide

There is at least some good news on the tobacco front, though

In Hong Kong, these include Smoking causes peripheral vascular disease with a photo of blackened, diseased toes, a call to Quit smoking for future generations, and the phone number for the Hong Kong governments Quitline: 1833 183.

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