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In addition, RA also causes damage to other tissues and organs such as the heart, kidneys, lungs, digestive system, eyes, skin, and nervous system (Giles, 2019

Compartmentation: Cytosol contains most cellular GSH, with significant pools in mitochondria and ER

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This suggests there is a delicate balance to CCL2 concentrations, and that deficiency can be as unfavorable as an excess ( Studies of monocytes infected with Cpn have shown a significant increase in CCL2, suggesting infection may lead to a pro-inflammatory state ( Similar to Cpn, SARS-CoV-2 infection can lead to an increased expression of pro-inflammatory cytokines by activating the ERK1/2 pathway ( CCL2, IL-6, and IL-8 (another pro-inflammatory mediator) have been found to be increased in AD brains and may play a significant role in the chronic inflammation that occurs in the CNS of these patients

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