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Neutrophils are also capable of expressing and secreting molecules that affect T cell functions, such as arginase 1 and inducible nitric oxide synthase (iNOS), which can hinder T cell proliferation and activation, thus regulating T cell-mediated immune responses to some extent (71)

The accumulation of metabolic waste products and alterations in pH can further contribute to a hostile TME, which can impair immune function and promote tumor progression

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Why does the randomized clinical trial methodology so often mislead clinical decision making