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Moreover, it has been shown that the phospholipase PNPLA1 belonging to the iPLA2 family in murine keratinocytes plays a crucial role in the biosynthesis of -O-acylceramide, a lipid component essential for the functioning of the skin barrier [61], and mutations in the PNPLA1 enzyme in both C- and N-terminal domains are associated with the development of autosomal recessive congenital ichthyosis (ARCI) [69, 70] causing abnormal lipid accumulation in fibroblasts and impairing the biosynthesis of -O-acylceramide [62]

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In models of IBD (IL-10 deficient mice and HLA-B27 rats), ER mRNA levels were decreased and colonic permeability increased [92]

Joint Injections: Trigger Points, Trigger Finger, & More Relieve myofascial pain with direct shots to the knots in your muscles, also known as trigger points

Extracellular redox state shift: a novel approach to target prostate cancer invasion

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