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In addition to their involvement in the stress response, GCs (cortisol, cortisone, and corticosterone) have several essential biological functions

They promote foods that enhance gut microbiota richness and alleviate systemic inflammation and fatigue [103,104,105]

10.3389/fpubh.2024.1444990 86 DaiberA.FrenisK.KunticM.LiH.WolfE.KilgallenA

Through comparative analysis of three geographically diverse gut metabolomic datasets (four case-control comparison) encompassing IBD cohorts and non-IBD controls (including patients with varying disease activity states), we identified significant pathway enrichment in aromatic amino acid metabolism, particularly involving tyrosine, phenylalanine, and tryptophan catabolism (Fig