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Description

2.1 5-Fluorouracil 5-FU is a metabolic inhibitor that interferes with nucleic acid metabolism by inhibiting cancer cells thymidylate synthase (TS) activity, blocking their DNA synthesis, and inhibiting their proliferation

As evidenced by our prior investigations, histone demethylases KDM1A and KDM5B, respectively, drive drug resistance, wherein targeted pharmacological inhibition using respective antagonists effectively reverses these resistance mechanisms