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While GLP-1 agonists may produce greater total weight loss, AOD-9604 more selectively targets fat tissue while preserving muscle mass

The peptide activates survival pathways including Akt signaling, promotes stem cell recruitment and differentiation, and upregulates matrix metalloproteinases (MMPs) for tissue remodeling

American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity

During the Biden administration, the FDA restricted compounding pharmacies from making these and other peptides, citing safety concerns

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