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Although no known inhibitor binds this area of the cavity, a HEPES molecule was serendipitously found in the TbTR structure solved in a complex with an inhibitor targeting the MBS ( Intriguingly, the interfacial cavity, whose entrance appears to be occluded by hit 71, has been exploited to carry out an alternative inhibition strategy of TR aimed at the disruption of the dimeric assembly (Supplementary Figure S3) highlights hot-spots corresponding to hit 71 and indicates the whole interfacial cavity as a significant druggable site

Early and progressive impairment of spinal blood flow-glucose metabolism coupling in motor neuron degeneration of ALS model mice

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Stinging at the injection site with the subcutaneous route, due to the quinolinium chemistry

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Scatter factor expression and regulation in human glial tumors