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It has been demonstrated to induce mitochondrial damage and both intrinsic apoptotic and mPTP-driven cell death 13,14,15,16 via signalling pathways, indicating that its mode of action may involve BAX and BAK1

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Morita N., Sovari A.A., Xie Y., Fishbein M.C., Mandel W.J., Garfinkel A., Lin S.F., Chen P.S., Xie L.H., Chen F., et al

Silveira MG, Brunt EM, Heathcote J, Gores GJ, Lindor KD, Mayo MJ Hepatology (Baltimore, Md.) 2010 Jul 52 1 349-59 The 5-D itch scale: a new measure of pruritus

After 6 days of intravenous injection of recombinant AIMP1 in a mouse xenograft model bearing human stomach cancer cells, the tumor volume and weight decreased significantly 102

Chronic exposure to toxins may deplete glutathione levels

Very recently, two families, each with two affected siblings, were reported