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This reaction might be strongly favoured inside cells, where GSH levels are in the millimolar range 16

Kim YS, Gupta Vallur P, Jones VM, Worley BL, Shimko S, Shin DH, et al

Prospects and challenges towards sustainable liver fluke control

58 The decrease in autophagy in aged HSCs leads to the accumulation of active and healthy mitochondria and increased metabolism, particularly increased oxidative phosphorylation, promoting accelerated myeloid differentiation of HSCs

Genomics 5:83

demonstrated that FK228, an HDAC inhibitor, induces histone hyperacetylation in synovial cells, leading to reduced levels of tumour necrosis factor (TNF-) and interleukin-1 (IL-1) and the inhibition of vascular endothelial growth factor production [34]