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Reconstitution is required

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[38] A 2009 review found that sleep loss had a wide range of cognitive and neurobehavioral effects including unstable attention, slowing of response times, decline of memory performance, reduced learning of cognitive tasks, deterioration of performance in tasks requiring divergent thinking, perseveration with ineffective solutions, performance deterioration as task duration increases

doi:10.1371/journal.pone.0040365 Philippova M, Joshi MB, Pfaff D, Kyriakakis E, Maslova K, Erne P, Resink TJ (2012) T-cadherin attenuates insulin-dependent signalling, eNOS activation, and angiogenesis in vascular endothelial cells