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Ongoing monthly operating costs (the stage budgets used throughout this guide): Stage 1, Ideation / pre-launch: under $1,000 per month Stage 2, Early-stage / post-launch: under $5,000 per month Stage 3, Expansion: under $10,000 per month These figures cover your software stack, compliance tooling, and core operations, not provider compensation or paid acquisition, which scale with your patient volume and can quickly become your largest line items

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integrating cfDNA/ctDNA dynamics with inflammatory markers (CRP/NLR) may refine early risk stratification and guide surveillance or adjuvant strategies (124, 125)