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Thiazide diuretics increase urinary excretion of zinc [36,37,38,39]

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Cu/Zn-containing SOD (SOD1) predominantly found in the cytosol, Mn-containing SOD (SOD2) mainly found in mitochondria and Cu-Zn-containing SOD (SOD3) found in extracellular tissues and fluids (Azadmanesh and Borgstahl, 2018)

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doi: 10.3390/ijms17060939 50 SuofuYLiWJean-AlphonseFGJiaJKhattarNKLiJet al

VTS is one of the most common causes (3560%) of non-palpable testes in children [2,3,4,5], probably caused by the atrophy and disappearance in fetal life of an initially normal testis