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The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions

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Research in obese mice demonstrated that AOD-9604 increases beta-3 adrenergic receptor RNA expression, restoring levels comparable to those in lean mice

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Protein misfolding, amyloid formation, and human disease: a summary of progress over the last decade