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Dihexa or its analogs were administered 5 minutes after scopolamine, either intracerebroventricularly at doses of 0.1 or 1 nmol), intraperitoneally at doses of 0.05, 0.25, or 0.50 mg/kg, or orally at doses of 1.25 or 2.0 mg/kg

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We hypothesize that interventions targeting these metabolic barrierssuch as inhibiting agmatinase (AGMAT) to reduce CAF infiltration as proposed by Wang et al., or selectively depleting glutathione in GPX4-high cloneswill unlock the cytolytic capacity of exhausted T cells [307]

And low levels of glutathione occur due to poor nutrition along with environmental toxins, stress, and also age

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