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Because it significantly slows gastric emptying, gastrointestinal side effects are common, affecting up to 30% to 50% of patients during initiation (Raja, 2025)

68 In a study in 50 healthy client-owned dogs scheduled for elective surgery, administration of melatonin, at 5 mg/kg body weight two hours prior to anesthesia, produced a calming effect and reduced the amount of anesthesia needed

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doi: 10.1016/j.bjid.2021.101594 46 VerstocktBSalasASandsBEAbrahamCLeibovitzhHNeurathMFet al