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Ghrelin has been shown to increase the release of GH which is amplified by co-administration of GHRH, and acts at the level of the hypothalamus and pituitary

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20 It is worth noting that gene polymorphisms of liver metabolic enzymes, such as UGT , SULT , and CYP2E1 , and some co-existing diseases, such as viral hepatitis, acute and chronic malnutrition, and nonalcoholic fatty liver disease, may increase the susceptibility to APAP-induced liver injury, even at a therapeutic dose

doi: 10.1016/j.jsbmb.2018.04.008 57 RosenfieldRLEhrmannDA

doi:10.1007/978-94-007-2199-9_18