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FIGURE 1 3.2.2 CSD theory Trigeminal afferent activation sets off the pain pathway, which sends information to the TG, the TNC, and finally to the brainstem and cortical structures involved in pain processing, resulting in pain (Zhang et al., 2011)

Association of the Anxiogenic and Alerting Effects of Caffeine with ADORA2A and ADORA1 Polymorphisms and Habitual Level of Caffeine Consumption

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Another study suggests that the formation of SCs aggregates is involved in the mechanism underlying BIPN (Watanabe et al., 2010)

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Still, DBS is the most preferred surgical technique, but there is a growing interest in new techniques like MR-guided focused ultrasound