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Mild or moderate cases may improve with nighttime bracing, reduced hand stress, controlled stretching, soft-tissue treatment, and management of contributing medical conditions

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doi: 10.1210/jc.2010-0490 125 FalutzJAllasSBlotKPotvinDKotlerDSomeroMet al

Practical considerations include that many patients inject in the evening, aligning with the bodys natural growth hormone cycle

GH has dropped enough to produce symptoms, but enough pituitary responsiveness remains for strong clinical results during this window