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Limitations of Current Evidence Several critical limitations characterize the current evidence base for these peptide therapeutics

Conflict of interest Flynn McGuire, Riley Martinez, Annika Lenz, Lee Skinner, and Dan Cushman declare that they have no conflict of interest

Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: A randomised controlled trial

As a prevailing pitfall, and unsuited over-simplification, such a NO-system complexity in functioning remained hidden in most studies using only one part regularly, mostly the NO-system inhibition as a theoretical background [97]

Studies demonstrate protection against brain edema, reduced inflammatory cytokines TNF- and IL-1, and enhanced neuronal survival following injury

Early in the COVID-19 pandemic, there was some speculation that LL-37 may be involved in altering the host response to SARS-CoV-2 as well, but data on this is still emerging