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Therefore, zinc has a protective potential against metabolic syndrome-associated oxidative stress through induction of transcription factors (including (ARE)-Nrf2 signaling) and a subsequent up-regulation of enzymatic and non-enzymatic antioxidants, induction of metallothionein synthesis, its structural role in Cu,Zn-SOD (SOD1), and, finally, its direct antioxidant activity

At the anterior pole, BMAL1 labelling was mainly detected in the epithelium, with less labelling evident in the fiber cells for each time point ( Figures 5AD )

Aside from the molecules mentioned above, several other compounds with anti-ferroptotic properties have demonstrated antifibrotic effects in various organs besides the lungs, and hold promise for potential therapeutic application in PF

Glutamine is the precursor for glutamate and is needed for GSH production and therefore antioxidant responses

Competing interests Anteneh Tesfaye Tefera, Debebe Worku Dadi, and Mulualem Tamiru Kassa are employees of BioTEI Inc., supplier of the Moringa seed meal

2019;33(1_supplement):662.21