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Vitamin D, exercise, and adequate protein intake all affect pathways implicated in cancer, yet we recognize their net benefit to health

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The mechanisms most relevant to knee pain: VEGF upregulation stimulates new blood vessel formation in cartilage and connective tissue, areas that are notoriously slow to heal due to limited blood supply Nitric oxide modulation regulates inflammation and promotes vasodilation, improving blood flow to damaged tissue Collagen synthesis accelerates organized collagen deposition at repair sites instead of disorganized scar tissue Tendon-to-bone healing particularly relevant at the patella tendon and other knee attachment points Animal studies across rat, rabbit, and canine models showed consistent findings across these pathways

Daily vitamin needs vary a lot - adults should get about 1.3 mg of vitamin B6 and 2.4 mcg of vitamin B12 daily

PMCID: PMC8524106

Its use significantly increased in recent years in the diet of people