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severe categories ( t = 3.24, p = 0.003)

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Metformin was studied in paclitaxel-treated mice, and the results indicate the effectiveness of metformin in attenuating hyperalgesia priming induced by paclitaxel through its stimulation of adenosine monophosphate-activated protein kinase (AMPK) [31]

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Patients were randomized to receive 1 gram acetaminophen IV q6hr for 48 hours or placebo