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They are characterized by decreased iron storage due to ferritin downregulation and increased expression of FPN and TfR1, all features consistent with a larger LIP [60, 61]

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10.1016/0026-0495(91)90033-S [DOI] [PubMed] [Google Scholar] 99.Olek RA, Samulak JJ, Sawicka AK, Hartmane D, Grinberga S, Pugovics O, et al

Moreover, the distinction between causal and correlational interpretations is critical

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Most ophthalmologists start treatment with one of the first-line therapy approved agents: a beta-blocker once daily in the morning or a prostaglandin analog once daily at night, depending on training, personal experience, and patients medical history