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Naltrexone modulates dopamine release following chronic, but not acute amphetamine administration: a translational study

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At concentrations that are high relative to the K m , the elimination rate is almost independent of concentrationa state of pseudo-zero order elimination

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CASE STUDY ANSWER Sixty-seven percent of total standard digoxin clearance is renal, so the standard renal clearance is 0.67 9 L/h = 6 L/h/70 kg with creatinine clearance of 100 mL/min and nonrenal clearance is (1 0.67) 9 L/h = 3 L/h/70 kg (see Table 31 for standard pharmacokinetic parameters)