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The procedure is a stereotactic neurosurgical operation under general anaesthesia: A small burr hole is made in the skull Under stereotactic guidance, a fine needle is advanced into the putamen (a deep brain structure) Progenitor cells are deposited at multiple sites in both putamina (bilateral transplantation) Phase I/II results (Sawamoto et al., Nature 2025) Patients: 7 (ages 5069) with idiopathic Parkinsons disease responsive to levodopa Follow-up: 24 months Serious adverse events: None Mildtomoderate adverse events: 73 total Efficacy (among 6 patients evaluable for efficacy): MDS-UPDRS Part III improved in the OFF state in 4 of 6 patients MDS-UPDRS Part III improved in the ON state in 5 of 6 patients Mean OFF-state improvement: 9.5 points (20.4%) Mean ON-state improvement: 4.3 points (35.7%) Hoehn-Yahr stage improved in 4 of 7 patients Imaging: F-DOPA influx rate constant (K) increased by 44.7% in the putamen, with greater increases in the high-dose group direct evidence that grafted cells survived and produced dopamine No graft overgrowth on MRI Can international patients get Amchepry in Japan

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Oleuropein regulates bile acid metabolism via modulating the gut microbiota, thereby alleviating DSS-induced ulcerative colitis in mice

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Second, GSNO may help maintain or restore endothelium derived NO signaling, preserving vasorelaxation, minimizing reperfusion-associated vasoconstriction, and supporting coronary perfusion

An interim analysis of an open-label study involving ten patients with GD1 revealed that NAC at a 3600 mg/day dose administered orally for three months showed trends to improve the levels of N-acetyl aspartate and glutamate, which are considered the validated MRS markers for neuronal health, as well as blood antioxidant and inflammatory biomarkers