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Ultimately, the radical chain reactions will be blocked by the antioxidant enzymes superoxide dismutase (SOD) in association with catalase or GPX that determines the complete free radicals scavenging (Winterbourn, 1993)

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Including enhanced drug availability, facilitated accumulation of antirheumatic drugs within arthritis joints via extravasation through leaky vasculature and inflammatory cell-mediated sequestration (ELVIS) effect, precise modifications for active targeting of inflammation, and controllable drug release