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5K) and, even though early and late apoptosis were not significantly upregulated individually, as monitored by Annexin V/PI, both showed an increasing trend after NUPR1 inhibition (Fig

Groups vulnerable to these deficiencies include individuals dealing with obesity, impaired nutrient absorption, renal issues, proton pump inhibitor (PPI) users, elderly individuals with elevated Clinical Frailty Scores, women, taller individuals, and post-bariatric surgery patients, especially those lacking postoperative care [3, 43,44,45]

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Excipients such as sorbitol, mannitol (sugar alcohols), lactose (in those with intolerance), and various binding agents or fillers may contribute to gastrointestinal symptoms

It is worth noting that there is no established link between standard-dose vitamin B12 supplementation and serious gastrointestinal pathology

These are two different timelines