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Spitz tumors in the adult population are managed more definitively, with complete excision and care more closely aligned with melanoma management, given the contrast in prognosis between pediatric and adult patients with Spitz tumors

Hepatic porphyrias are transmitted as an autosomal dominant trait

In healthy individuals, the intestinal barrier prevents LPS from entering the circulation

Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts

Plant Physiol Biochem 199:107727

Additional neurologic findings such as developmental delay, seizures, hypotonia with or without neuromuscular disease manifestations, cognitive impairment, myopathy, and cranial nerve dysfunction have been reported in up to 29% of CVS patients allowing to propose a subtype called CVS plus (85)