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doi: 10.1136/hrt.75.6.573 56 ObreE.RossignolR

[39] Biological importance [edit] Cysteine and cystine [edit] As the functional group of the proteinogenic amino acid cysteine, the thiol group plays a very important role in biology

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PSC mainly affects the large bile ducts with a characteristic pattern of multifocal strictures and dilations, while PBC targets small intrahepatic bile ducts

Notably, while classical organoid systems have long been established exclusively from crypt-resident stem cells 27,28 , our findings challenge this longstanding paradigm by demonstrating that mutation-free villus-derived cells can indeed establish organoids via fetal reversion, revealing remarkable regenerative flexibility of the adult intestinal epithelium

Moreover, it markedly prolonged the inhibition of PFC neurons following electrical stimulation of the ventral tegmental area, which could be prevented using a 5-HT 2A antagonist (Godbout et al., 1991)