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In addition to the regulation of 1 C metabolism, emerging evidence shows that enzymes in the one-carbon metabolic network also have important non-canonical functions, commonly referred to as moonlighting functions [5]

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When cultured murine skeletal muscle cells were atrophied by the pro-inflammatory cytokine TNF-, not only did trimetazidine significantly reverse the reduction in myotube size, it also increased myosin heavy chain expression and induced hypertrophy [160]