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PLoS ONE 10, e0145399

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Kelley RK, Verslype C, Cohn AL, Yang TS, Su WC, Burris H, et al

This study successfully identified C5 and SCP2 as promising drug targets through Mendelian randomization and Bayesian colocalization, and highlighted beta-Amyrone as a potential dual-target inhibitor with strong binding affinity to both proteins, paving the way for innovative treatment strategies

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-20C, 1 month (protect from light) Biological Activity apoptosis and inflammatory responses by up-regulating the expression level of ER , thereby improving cognitive function in Alzheimer's disease models