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Clinically, the U-shaped curve illustrates the risks associated with excessive antioxidant supplementation in the absence of proper professional oversight and individualized patient assessment [23]

The production of NO was subsequently quantified using the Griess assay, which measured nitrite concentration as an indicator of NO release

Though, 2,3-DPG level of a small number of newborns ( n 12) was reported to increase during the first two weeks of life, and this was paralleled by the changes in thyroxine (Reference Versmold, Horn and Windthorst58)

Furthermore, increased mucosal permeability in UC exposes the immune system to bacterial antigens, leading to abnormal immune responses that exacerbate inflammation and disrupt immune regulation