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Polyol pathway

Lei M, Zhang YL, Huang FY, Chen HY, Chen MH, Wu RH, et al

However, supplementation with normal concentrations of SCFAs (67.5 mM acetate, 40 mM butyrate, 25.9 mM propionate) mitigated this inhibitory effect (119)

Foods , 10 (2477), 116

Additionally, it is crucial to account for the interactions and synergies between various repair pathways, as the resolution of DNA damage in tumor cells often engages multiple mechanisms

Four possible factors mainly induce this process: massive release of the iron homeostasis regulator Hepcidin, excessive iron influx dependent on the transferrin receptor (TfR), which mediates cellular iron uptake through endocytosis of iron-loaded transferrin during SARS-CoV-2 replication, attack of hemoglobin to release free iron into the circulation, and inhibition of GPX4 by SARS-CoV-2 (107109)