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& Jabeen, S

Gingele, S

Beyond its immune-related roles, tryptophan is involved in hepatic function, specifically in the synthesis of niacin (vitamin B3), which is essential for energy metabolism and DNA synthesis (Bouma et al., Similar to GWS and ME/CFS, disruptions in purine metabolism are suspected to play a role in the pathophysiology of FM

Biol Psychiatry 2008, 64(5):361368

This process is mediated by the Sonic Hedgehog (SHH) signaling pathway, which promotes metaplastic transformation and enhances the immunosuppressive activity of MDSCs through mechanisms involving key suppressive factors such as Arg-1 and iNOS